Ayiti Game about poverty in Haiti.
Persuasive Games Ian Bogost's development company for serious games. Topics range from clean energy to food consumption to immigration policies.
Every Day the Same Dream An "existential riff on the theme of alienation and refusal of labor"
Watercooler Games. Yet another listing of Bogost Serious games.
Darfur is Dying As the title implies, a game about the crisis in Darfur.
Peacemaker. Game about the Israeli-Palestinian conflict.
Under Siege First-Person Shooter from the perspective of a Palestinian youth.
Global Conflict Developed by the Serious Games Initiative, a series of games designed to educate about global conflicts.
America's Army US Army recruitment video game.
CyberCIEGE Game designed to teach network security principles.
Games for Change Organization that collects games designed to enact social change.
Slime Forest Adventure Game to teach you kanji and hiragana
Re-mission: theraputic game meant to educate young cancer patients about what is going on inside their bodies.
Oregon Trail: an educational game showing the over land journey settlers endured on their way to occupy Oregon.
Safe Passage: a game about Palestinians moving about occupied territories.
Commercial Games
Final Fantasy Series (link to XIII)